Unique Ingredient Hobamine® Receives Health Canada NPN Approval
A Groundbreaking Step for Cellular Health in Canada TSI Group’s innovative cellular health ingredient, Hobamine®, has received a Natural Product Number (NPN) #80138909 from…
A Groundbreaking Step for Cellular Health in Canada TSI Group’s innovative cellular health ingredient, Hobamine®, has received a Natural Product Number (NPN) #80138909 from…
Hobamine® (2-hydroxybenzylamine acetate or 2-HOBA) is a naturally occurring compound involved at the cellular level. It targets and neutralizes reactive dicarbonyl electrophiles, such as isolevuglandins (IsoLGs) — harmful byproducts of lipid peroxidation that can damage DNA, proteins, and cell membranes.
This precision-based action makes Hobamine® a powerful tool in the fight against oxidative stress and aging at the cellular level.
Hobamine® offers a more targeted approach to oxidative balance, helping the body neutralize damaging byproducts without disrupting normal immune or metabolic function.
Potential Benefits of Hobamine®:
– Support healthy cell function
– Balanced immune response
– Protection against oxidative stress and inflammation
Every day, cells are exposed to stress from lifestyle, environmental factors, and metabolic activity. Over time, this can impact how well cells repair and function.
Hobamine® helps support resilience at the cellular level, working to preserve DNA and protein integrity and maintain optimal cell performance—even under stress. Its mechanism is designed to promote cellular defense where and when it’s needed most.
To learn more about Hobamine® and the science behind its unique mechanism, read the full feature from PricePlow.
The SupplySide Supplement Journal Product Development Guide delves into the latest trends and strategies, offering brands a roadmap to thrive in this growing market, which is expected to expand by 8.5% by 2027. With a shift from “anti-aging” to “healthy aging,” today’s products appeal to multigenerational consumers, from Boomers to Gen Z, who seek solutions that promote long-term well-being.
A standout ingredient in this space is Hobamine® (2-HOBA). This unique compound offers a novel approach to cellular health by selectively scavenging isolevuglandins (IsoLGs), highly reactive molecules formed during oxidative stress. Unlike other compounds, Hobamine® protects cells without interfering with normal physiological processes, making it an essential nutrient for supporting overall cellular health and vitality as we age.
With opportunities to create targeted and broad-spectrum formulations, the healthy aging category is ripe for innovation. Download the SupplySide Supplement Journal Product Development Guide to explore how brands can lead the way in delivering products that empower consumers to age gracefully and vibrantly.
Hobamine, TSI Group’s latest ingredient breakthrough, has garnered recognition as one of the standout discoveries of the year. As we take pride in reflecting on the past year, we eagerly anticipate exploring new studies and findings that await on the horizon. But first, let’s revisit some notable highlights from 2023.
In a study funded by the NIH and published in the journal Inflammation, it was discovered that supplementing with 2-HOBA positively influenced up to 15 inflammatory biomarkers in healthy individuals, fostering a well-balanced immune system.
“Normally, inflammation is self-limiting, and its resolution is the first step in the repair and regeneration of injured tissues. Failure of inflammation resolution can lead to the progression of several diseases,” says John A. Rathmacher, Ph.D., Director of Clinical Research and Laboratory Services at MTI BioTech, Inc. That’s why a balanced immune system is incredibly important.
The NutraIngredients-USA Awards continue to recognize excellence in the dietary supplement industry. Across 17 diverse categories, these awards commend outstanding ingredients, finished products, companies, and individuals in the nutrition sector.
The Nutrition Research Project of the Year Award was awarded to the new NIH-funded study titled “Inflammation Biomarker Response to Oral 2-Hydroxybenzylamine (2-HOBA) Acetate in Healthy Humans” focused on Hobamine.
In a recent episode of The Natural View podcast featuring Todd Pauli and Maggie Jaqua, special guest Shawn Baier, VP of Business Development at TSI Group, delves into the topic of healthy aging, shedding light on often overlooked components and nutritional ingredients that promote the aging process.
During the podcast, Shawn Baier provides an in-depth exploration of Hobamine (2-HOBA), elucidating its nature, functionality, and why it stands out as a noteworthy supplement.
Throughout various publications in 2023, Hobamine (2-HOBA) has emerged as a groundbreaking ingredient taking center stage.
Positioned as a contributor to healthy aging, Hobamine employs a distinctive approach to combat oxidative stress, all the while preserving normal physiological function and pathways.
Despite a 4.3% decline in sales for immune health supplements in the last year, the category remains relevant. The decline is slowing, and experts believe it won’t plummet to the levels seen after the pandemic’s peak.
One significant challenge faced by manufacturers, vendors, and retailers is dealing with overstock issues as they stocked up on immune products during the pandemic. However, this overstock situation has opened the door for innovation rather than indicating reduced importance for immune support.
A consumer survey conducted by Kerry Group across 16 countries and 13,000 participants revealed that immune support is the top health benefit sought across all age groups. Nevertheless, people’s ideas about how to support healthy immunity are evolving.
Consumers are now taking a more proactive, long-term approach to their immune health. This shift goes beyond traditional immune health products, such as vitamin C during the winter, as people recognize the importance of factors like sleep, cognitive health, and mood support in overall wellness. There’s a growing awareness of the connection between stress, sleep, and immune function.
Adaptogens are gaining popularity for their role in helping the body adapt to stress, thereby supporting immune health. The global adaptogens market is experiencing significant growth, driven by consumer demand for a balanced immune system.
Mushrooms, particularly medicinal mushrooms like turkey tail, chaga, reishi, and others, have seen a surge in interest due to their immune-supporting properties. This trend is expected to continue, with the global functional mushroom market projected to expand significantly.
As consumer awareness of immune health continues to grow, “so is the demand for well-rounded formulas and solutions,” said Shawn Baier, TSI Group’s VP of Business Development. “Focusing on one stick pack a day dosing can make immune health products more mainstream and popular among the Millennials and Gen Z generations,” he added.
TSI reports that their branded ingredient, Hobamine (2-HOBA), has demonstrated in a new study the ability to enhance up to 15 inflammatory biomarkers in individuals with good health, thereby contributing to the maintenance of a well-balanced immune system.
To learn more about immune health and ingredients targets to this market read the full article on Nutraceuticals World.
The cellular health industry continues to grow with more and more ingredients coming to the forefront. As this category evolves, it’s hard for consumers to navigate the market. Brands need to step up their game to educate consumers on the science behind these ingredients.
“Aging research has evolved in recent years,” says Aileen Stocks, president of wellness brands at Nestlé Health Science. “Researchers now know there is a time-related decline of several cellular mechanisms that often starts in our 40s and accelerates in our 60s. One of the key drivers behind this age-associated cellular decline is a decline in mitochondrial function.”
Stocks goes on to discuss how Nestle’s branded Celltrient products aim to target these issues that play a role in age-related decline.
A notable obstacle within the cellular health market is the absence of a clear definition of what cellular health is. If consumers don’t understand cellular health, why would they invest in supplements to improve it?
“We need to step up consumer education so that people understand how a product or ingredient supports their goals,” says Shawn Baier, VP of Business Development at TSI Group. “One of the smartest ways to accomplish this is with research designed to enable brand marketers to use proven and regulatory-compliant language so consumers can clearly understand the importance and benefits of specific ingredients and products.”
Baier goes on to discuss how ingredients like glutathione, NAD, NAC, and Hobamine (2-HOBA) are validated ingredients to support cellular health.
To read the full article in Nutritional Outlook please follow the link below.
In The Natural View podcast with Todd Pauli and Maggie Jaqua, they have special guest Shawn Baier, VP of Business Development at TSI Group, to discuss healthy aging, overlooked component, and nutritional ingredients to promote healthy aging.
There are many various categories to focus on when we talk about healthy aging like joints, bones, and cognitive health. One area that tends to get overlooked when it comes to healthy aging is muscle health.
Unfortunately, we will all experience age-related muscle loss and if not addressed at all it can become a debilitating issue. Our muscles carry out the physical demands of life and preventing muscle loss is easier than trying to restore lost muscle mass and strength.
The good news is there is an ingredient that is clinically proven to help prevent muscle loss – myHMB, scientifically known as beta-hydroxy beta-methylbutyrate or HMB.
HMB in the past has been predominately known as a supplement for bodybuilders to help build muscle and improve recovery, but there is an array of research showing its potential in aging demographics to help prevent muscle loss during times of inactivity like bed rest after an illness or injury. HMB can benefit any individual that wants to improve quality of life as we age.
We all experience oxidative stress in our lives, and while we can mitigate some of it, we cannot eliminate it. Factors such environmental factors, lack of sleep, poor nutrition, alcohol, overexercising can all cause oxidative stress and when excessive oxidative stress happens it creates highly reactive molecules called free radicals and these can have a negative impact on the health of our cells and bodies.
Hobamine, or 2-hydroxybenzylamine (2-HOBA), is a naturally occurring compound that is at the forefront of new developments to support cellular health, particularly as we age.
Hobamine (2-HOBA) works by rapidly capturing specific reactive compounds formed by oxidative stress. This capture prevents those compounds from binding to and damaging other cellular components like proteins, lipids, or DNA and impeding normal function of the cell.
Dive deeper into these topics by watching or listening to the full podcast on The Natural View!
Todd Runestad, Natural Products Insider content director spoke with Douglas S. Kalman, Ph.D., clinical associate professor at Nova Southeastern University in Florida to gain his expert insight on the top three ingredients that are effective in the sports nutrition arena. According to Kalman, his top 3 ingredients were Hobamine, HMB, and Creatine. Here is a little insight on why he chose these 3 ingredients.
Our lives are filled of stress and high-intensity exercise also induces stress on the body. This creates what’s called reactive oxygen species in the body that can cause damage to cells, and this can limit performance.
Hobamine is the patented ingredient scientifically known as 2-hydroxybenzylamine or 2-HOBA. Hobamine (2-HOBA) works uniquely by acting specifically against reactive oxygen species responsible for oxidative damage without blocking the processes needed for cell function. This is an advanced approach to reducing the impact of oxidative stress. And therefore, can mitigate damage done from exercise to help enhance performance by extending it or allowing a higher output capacity.
“Another ingredient that I think is under appreciated for its ability to have positive impact on health is an older ingredient HMB”, states Kalman.
HMB, scientifically known as beta-hydroxy beta-methylbutyrate, has been around for more than 30 years. This tried-and-true ingredient helps to reduce delayed-onset muscle soreness (DOMS) by reducing muscle protein breakdown and increasing muscle protein synthesis. This allows consumers to recover faster allowing them to train more often and see results quicker.
Creatine is another ingredient that has been well-researched and widely used among athletes for quite a few years. Creatine helps to increase ATP production in the body to reduce muscle fatigue and fuel performance, but new data on Creatine is showing that it may also have cognitive benefits.
Watch the video or read the article featured in Natural Products Insider here.
NutraIngredients-USA Awards persist in acknowledging excellence within the dietary supplement industry. With 17 different categories to enter, the awards honor the best and brightest ingredients, finished products, companies and people in the nutrition industry.
The new NIH-funded study on Hobamine, Inflammation Biomarker Response to Oral 2-Hydroxybenzylamine (2-HOBA) Acetate in Healthy Humans, received the Nutrition Research Project of the Year Award.
This study showed the impact of 2-HOBA (Hobamine) supplementation on inflammatory biomarkers in healthy individuals and addressed the concern of maintaining a balanced immune system to prevent the progression of several diseases associated with chronic inflammation. The findings of the study suggest that supplementing with 2 HOBA (Hobamine) can support a balanced immune system by enhancing inflammatory biomarkers in healthy individuals and reducing the levels of the protein TWEAK, which stimulates inflammation and tumor development.
“This interesting and well-designed study, funded by NIH, found that 2 HOBA (Hobamine) supplementation may promote a healthy balance of the immune system by improving inflammatory biomarkers in healthy individuals. Published in a peer review journal that indicates strong credibility, and it therefore provides opportunities for formulators and developers to add Hobamine, to their immune focused formulations, enabling healthy individuals to be more proactive about maintaining their immune readiness. The novelty of the ingredient and the impacts on inflammatory markers in healthy people really helped this project stand out,” stated Stephen Daniells, PhD, Editor-in-Chief of NutraIngredients-USA.
Science continues to evolve on the human body and how there are key markers in human cells and DNA that can give us a better idea on the aging process. With this new knowledge, many specialty ingredients are coming to the forefront to help try to set back our cellular clock.
“Even though there is still no consensus about whether aging is biologically programmed, almost all gerontologists agree aging is a clinical disease responsible for the vast majority of deaths among the world’s populations,” said Marianne McDonagh, Vice President of Sales for Bioenergy Life Science, Inc.
Telomerase is an enzyme that plays a crucial role in the maintenance and protection of our DNA. It is responsible for the extension and preservation of telomeres, which protect caps found at the ends of our chromosomes. The production of telomerase declines with age, and the shortening of telomeres has been linked to various age-related diseases.
Another important process that has been linked to cellular health is the process of senescence. This is where the cells are unable to continue to multiply even in optimal conditions. This process increases with age and can cause cells to express pro-inflammatory cytokines and other toxins that impair tissue function.
“All of these hallmarks represent a reason why the aging of our cells can affect our lives significantly. With a longer lifespan, we don’t always experience a longer health span or high quality of life,” said Shawn Baier, Vice President of Business Development at TSI Group. “It is important to note that supplementation won’t completely reverse cellular aging, but it can address some of the negative effects connected to it.”
Researchers are looking at ingredients to address cellular health, specifically looks at two primary outcomes:
• Inducing the death of senescent cells
• Improving mechanical integrity of healthy cells
TSI Group has recently launched the branded compound Hobamine (2-HOBA). A recent NIH-funded study published in Inflammation showed that 2-HOBA was linked to positive changes in 15 inflammatory biomarkers in two small cohorts of younger and older adults. This ingredient has the potential to ameliorate age-related declines in the immune system’s ability to self-limit its responses. 2-HOBA works as a scavenger of a pro-inflammatory reactive lipid called IsoLG. This can help to prevent the body’s formation of reactive oxygen species (ROS) from cascading out of control. As a result, ROS are neutralized before they react with DNA, proteins, and other components of the cell.
To read more about this topic please follow the link below to the full article in Nutraceuticals World magazine.
